Get Permission Kumar, Anand, and Bhoi: Mesenchymal stem cell-derived multivesicular bodies: Is it innovative novel cell-based therapeutic adjunct for trauma hemorrhagic shock patients?

Journal Information

Journal ID (nlm-ta): Innovative Publication

Journal ID (publisher-id): Innovative Publication

Journal ID (journal_submission_guidelines): https://www.innovativepublication.com/journal/IJIRM

Title: IP Indian Journal of Immunology and Respiratory Medicine

ISSN: 2581-4222

Article Information

Copyright: 2023

Date received: 28 February 2023

Date accepted: 15 April 2023

Publication date: 3 May 2023

Volume: 8

Issue: 1

Page: 37

DOI: 10.18231/j.ijirm.2023.009

Mesenchymal stem cell-derived multivesicular bodies: Is it innovative novel cell-based therapeutic adjunct for trauma hemorrhagic shock patients?

[] Manoj Kumar[1]

Email: manojssmc@gmail com

Designation:

Associate Professor

[] Kavneet Anand[2]

Designation:

Associate Professor

[] Sanjeev Bhoi[3]

Designation:

Professor and HOD

 

Dept. of Microbiology, Sukh Sagar Medical College & Hospital Jabalpur, Madhya Pradesh India

Dept. of Dentistry, Sukh Sagar Medical College & Hospital Jabalpur, Madhya Pradesh India

Dept. of Emergency Medicine, AIIMS Jai Prakash Narayan Apex Trauma Center New Delhi India

Multivesicular bodies (MVBs) is very small (30–1000 nm) membrane-bound vesicles, also called extracellular vesicles (EVs). MVBs are secreted from intracellular matrix through the blending with the plasma membrane. MVBs also released from different cells types under normal and abnormal situations. Interesting, MVBs hold complex of delivery molecules, contain proteins and RNAs, and communicate this message to nearby cells to alter immune system, cell death, formation of blood vessels and inflammation. Previous studies reported that MSC-MVBs act as anti-inflammatory effects in many inflammations associated infection by delivering the complex of cargo molecule (miRNAs and immunomodulatory proteins) to macrophages. MSC-MVBs may promise used as an innovative stem cell free therapeutic to treat HS-induced lung injury. 1, 2, 3 MSC-MVBs can be innovative therapeutic option for the T/HS patients. Need to be attention.

Figure 1

 IL-10 and immune reactivity via B-Cells. 4

https://typeset-prod-media-server.s3.amazonaws.com/article_uploads/bb750b86-cb5e-4238-a931-1948087a7ab1/image/2564b339-71de-4945-9294-6e9995073458-uimage.png

Source of Funding

None.

Conflict of Interest

None.

Acknowledgement

None.

References

1 

M Kumar S Bhoi Impaired hematopoietic progenitor cells in trauma hemorrhagic shockJ Clin Orthop Trauma2016742825

2 

M Kumar S Bhoi S Keshava Human-induced pluripotent stem cells derived hematopoietic failure among trauma hemorrhagic shockJ Clin Orthop Trauma201910226973

3 

M Fioranelli RM Grazia Twenty-five years of studies and trials for the therapeutic application of IL-10 immunomodulating properties. From high doses administration to low dose medicine new paradigmJ Integr Cardiol2014112610.15761/JIC.1000102

4 

Y Zhang X Zhang H Zhang P Song W Pan P Xu Mesenchymal Stem Cells Derived Extracellular Vesicles Alleviate Traumatic Hemorrhagic Shock Induced Hepatic Injury via IL-10/PTPN22-Mediated M2 Kupffer Cell PolarizationFront Immunol20221281116410.3389/fimmu.2021.811164

5 

A Zeineddin F Wu JF Dong H Huang L Zou W Chao trauma-derived extracellular vesicles are sufficient to induce endothelial dysfunction and coagulopathyShock20225813844

6 

DR Potter BY Miyazawa SL Gibb X Deng PP Togaratti RH Croze Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and traumaJ Trauma Acute Care Surg201884224556

Keywords

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Subject: Letter to Editor

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Article History

Received : 28-02-2023

Accepted : 15-04-2023


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https://doi.org/ 10.18231/j.ijirm.2023.009


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