Burden of smoking on the pulmonary diffusing capacity in asymptomatic smokers with chronic kidney disease in comparison to non-smokers with chronic kidney disease

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Original Article

Author Details : Prasanna Purna K, K Kalyani*, M Manoj Kumar, K Sai Sindhu, K Venkata Manohar

Volume : 4, Issue : 3, Year : 2019

Article Page : 150-153

https://doi.org/10.18231/j.ijirm.2019.034

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Abstract

Background: The study was aimed to assess the additional risk of smoking as a risk factor on lung function and gaseous exchange by measuring diffusion capacity of lung for carbon monoxide (D_LCO or T_LCO) in chronic kidney disease patients (CKD) on hemodialysis.
Methodology: This was a cross-sectional observational study among smokers and non-smokers with chronic kidney disease who were clinically stable in the last four weeks, without a past history of pulmonary and cardiac disorders. Spirometry and D_LCO tests were performed within 24 hours after hemodialysis.
Results: There were 40 CKD subjects on hemodialysis included in the study and were categorized into two groups as smokers & non-smokers. Smokers which included current smokers and forever smokers. All were males with the median age of 49.47 years and mean body mass index of 22.85 ± 2.29 kg/m² and with a mean hemoglobin level of 9.59 ± 1.58 g/dl among Non-smokers and 8.63 ± 1.51 g/dl among smokers. The mean of D_LCO among non-smokers with CKD was 49.35% of LLN of the normal value of D_LCO which is mild to moderate degree of reduction and 25.48% among smokers with CKD which is of a severe degree of reduction. There was a significant relation between D_LCO reduction with smoking history and also with CKD with a p-value of <0>
Conclusion: Reduction of diffusion capacity of the lung is common in chronic kidney disease patients even though not symptomatic. Risk factors for D_LCO reduction like smoking further increase the disease burden adding to further morbidity with more decrease in D_LCO.

Keywords: Carbon monoxide diffusing capacity; Chronic kidney disease; Smokers; Non-smokers.

How to cite : Prasanna Purna K, Kalyani K, Kumar M M, Sindhu K S, Manohar K V, Burden of smoking on the pulmonary diffusing capacity in asymptomatic smokers with chronic kidney disease in comparison to non-smokers with chronic kidney disease. IP Indian J Immunol Respir Med 2019;4(3):150-153

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