A study on the levels of IgE as a biomarker in the management of bronchial asthma patients

---

Original Article

Author Details : Kavitha Devi M, Yuvarajan S, Vickram Reddy, Kalaikovan B

Volume : 1, Issue : 3, Year : 2016

Article Page : 58-62

Suggest article by email

Get Permission

---

Abstract

Background: IgE is a major contributing factor for the development of bronchial hyper responsiveness in asthmatics. Serum IgE levels also shows association with degree of airflow obstruction. Therefore, a study was undertaken to estimate the serum IgE level in bronchial asthma patients, and to correlate the severity of airway obstruction with serum IgE level in bronchial asthma patients. A total of 75 cases in the age group of 21-60 years, of Tertiary care Hospital, Madagadipet, Puducherry-India was included in the study. Spirometry with reversibility testing was done in all cases. Serum IgE level was estimated using Quantia IgE, which is a turbid metric immunoassay. Patients with bronchial asthma had elevated serum IgE, which increased with increase in the severity of airflow obstruction and it was found to be statistically significant (p <0.05). It was concluded that Serum IgE level increases as the severity of airflow obstruction increases. It helps to classify the Bronchial asthma patients based on IgE and to guide anti IgE therapy for the patients with difficult to treat allergic asthma and to assess its response.

Keywords: Allergic asthma-; Serum IgE; Severity of obstruction; Spirometry-IgE therapy

How to cite : Kavitha Devi M, Yuvarajan S, Reddy V, Kalaikovan B, A study on the levels of IgE as a biomarker in the management of bronchial asthma patients. IP Indian J Immunol Respir Med 2016;1(3):58-62

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.