Cytomegalovirus and Epstein-Barr virus infections in pediatric patients of choledochal cyst

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Original Article

Author Details : Anil Kumar Ram, Prema Menon, Ravi Prakash Kanojia, Alka Bhatia, Ranjana Walker Minz, Yashwant Kumar*

Volume : 9, Issue : 2, Year : 2024

Article Page : 58-61

https://doi.org/10.18231/j.ijirm.2024.012

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Abstract

Objectives: Association of viral infection with obstructive jaundice is well-known however frequency of cholangiotropic virus infection in pediatric choledochal cyst is not known.
Materials and Methods: IgG and IgM antibodies against Cytomegalo virus (CMV) and Epstein Barr virus (EBV) in 48 children with choledochal cysts and 26 controls were analysed using ELISA.
Results: We found significantly higher anti-CMV IgG and IgM in patients (95.8% and 77.1%, respectively) compared to controls (73.1% and 42.3%) and a notable prevalence of anti-EBV antibodies among both groups (83.3% versus 65.4% IgG and 77.1% versus 46.1 for IgM in patients and controls respectively). Moreover, 79.2% of patients were positive for both anti-CMV and anti-EBV IgG, and 62.5% for both IgMs.
Conclusion: This pilot study suggests that infection with CMV, EBV, or both is frequently seen in pediatric patients with CDC. Molecular screening and follow-up in a larger cohort is therefore required for further validation.
 

Keywords: Choledochal cyst, Cholelithiasis, Cytomegalovirus, Epstein Barr Virus

How to cite : Ram A K, Menon P, Kanojia R P, Bhatia A, Minz R W, Kumar Y, Cytomegalovirus and Epstein-Barr virus infections in pediatric patients of choledochal cyst. IP Indian J Immunol Respir Med 2024;9(2):58-61

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