A study of antibody response to Covid-19 infection

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Original Article

Author Details : Ashish Diwan, Swapnil Jain*, Ravendra Singh, Arti Julka

Volume : 8, Issue : 1, Year : 2023

Article Page : 19-23

https://doi.org/10.18231/j.ijirm.2023.005

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Abstract

Background: The Coronavirus disease 2019 is a disease caused by the etiological agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was a newly identified β-coronavirus that had spread rapidly around the world, resulting in a very high number of infections and deaths, threatening public security, and placing a heavy burden on global healthcare systems and economy. The present study was done to study antibody response in COVID-19 infection.
Materials and and Methods: The study was carried out in the Department of Respiratory Medicine, R.D. Gardi Medical College, Ujjain, India after approval by ethics committee. The post COVID-19 cases attending respiratory medicine OPD were included in the study.
Results : The present study was conducted in 122 patients. The mean age of the patients was 51.20±14.21 years, median age was 54.5 years, the minimum age was 14 years and the maximum age was 80 years, the most number of COVID-19 infection cases was in the elderly age group of more than 50 years. The severity of disease was seen in those above 50 years of age (57.3%) with p>0.05. Among the severe cases mean age of the cases was 49±17 years, in moderate cases mean age 52±14 and among mild group of cases mean age was 51±15 years.
In the present study there were 73.8% males and females were 26.2% Among COVID-19 cases who reported in the OPD the maximum that is 86 (>70%) patients had moderately severe disease, while severe cases were only about 14 %. Mild cases were 15.6%.
In the present study RT-PCR were negative in 36(29.5%) as against 86 (70.5%) were confirmed cases of COVID-19 and among positive cases 40 % cases became negative between 6-10 days.
Among severe disease cases mean SARS COV2 antibody 650.06±240.47 was significantly higher as compare to moderate cases 461.49±331.41 and mild cases 404.11±240.47.
Conclusions : India has the world’s largest vaccination program. COVID-19 antibodies estimation are important tests carried out to determine the response of the body against COVID-19 infection.
Our results show a significant association between SARS COV2 antibody and the severity of disease.
 

Keywords: SARS-CoV-2, Coronavirus disease 2019, Neutralising antibodies, Persistence, Spike glycoprotein, Receptor binding domain, B cells, T cells, Convalesce

How to cite : Diwan A, Jain S, Singh R, Julka A, A study of antibody response to Covid-19 infection. IP Indian J Immunol Respir Med 2023;8(1):19-23

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