COVID-19 Study of biochemical haematological parameters in patients dying from COVID-19 in a tertiary care centre

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Original Article

Author Details : Ramakrishna Rachakonda*, Kiranmayi Abburi, Sai Ramya Gonuguntla, Bhavanarayana Jannela, Chakradhar Bolleddu, DVC Nagasree

Volume : 6, Issue : 2, Year : 2021

Article Page : 94-97

https://doi.org/10.18231/j.ijirm.2021.021

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Abstract

Background: COVID-19 pandemic resulted in a death of 419 patients among total admissions of 10682 with a death rate of 3.92% in the tertiary care COVID-19 hospital. We studied the biochemical and hematological parameters among 241 patients who died of the disease.
Results: CRP values were raised above 12mg/L in 58% of patients. 83% of patients had elevated LDH levels of >250 IU/L. Procalcitonin levels were above 0.5 microgram/L in nearly 66% of patients. Serum ferritin was more than 500 micrograms/L in 51% of patients. Elevated IL-6 were found in 83% of patients making it a significant inflammatory parameters. D-dimer levels were more than 500ng/ml in 74% of patients. HS Troponin I was raised in 83% of patients. Leukocytosis of more than 11000/Cu mm was seen in 38%. Leukopenia was seen in 35%. Thrombocytopenia was seen in 27% and normal platelet count was seen in 62%.
Conclusions: Biochemical parameters help in assessing the severity of inflammation in COVID-19 disease. They aid in the process of treatment particularly anticoagulants and corticosteroid. Specific parameters like IL-6 can help in decision making by treating physician regarding the use of anti IL-6 drugs like Tocilizumab. Elevated HS troponin I in our study showed myocardial injury played a significant role in mortality of COVID 19 patients at our centre.

Keywords: Creactive protein (CRP), Ferritin, Ddimer, Procalcitonin (PCT), Lactic dehydrogenase (LDH), IL6, HS Tropanin I.

How to cite : Rachakonda R , Abburi K , Gonuguntla S R, Jannela B , Bolleddu C , Nagasree D , COVID-19 Study of biochemical haematological parameters in patients dying from COVID-19 in a tertiary care centre. IP Indian J Immunol Respir Med 2021;6(2):94-97

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