Assessment of serum total IGE levels in smokers, non smokers and ex smokers and its relation to lung function, airway symptoms and atopic predisposition

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Original Article

Author Details : Swetha Madas, C Malliakarjuna Reddy*, M Hima Bindu

Volume : 4, Issue : 4, Year : 2019

Article Page : 210-213

https://doi.org/10.18231/j.ijirm.2019.048

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Abstract

Introduction: Many studies have shown an association of smoking with many of the health consequences
such as stroke, cardiovascular diseases, chronic respiratory illness, lung cancer and impaired pulmonary
function. Increased levels of IgE is found in these people, especially in addition to allergic diseases.
Materials and Methods: 310 patients, both men and women above the age of 18 years were included
into the study. Blood was collected for absolute eosinophil count and detection of IgE levels. Pulmonary
Function test was done for all the patients.
Results: Out of the 310 patients 22.3%were male smokers and 5.2% were female smokers. The difference
in the total serum IgE count was highly significant in the smokers, with the mean being 329.23 71.3
IU/ml, 28.94 9.2 IU/ml in non smokers, 194.3 23.55 in ex-smokers and 199.3 23.64IU/ml in passive
smokers. The Eosinothil count was also significantly high in the smokers, followed by ex smokers, passve
smokers in comparison to the non smokers. The FVC was the lowest in the smokers and in the normal
range in the non smokers.
Conclusion: Smoking is one of the most common modifiable risk factors to a number of diseases prevalent
in man. It is associated with the increase in IgE levels, making the patient more sensitive to allergens.

Keywords: Atopy, Allergens, Immunoglobulin E, Smoking

How to cite : Madas S, Reddy C M, Bindu M H, Assessment of serum total IGE levels in smokers, non smokers and ex smokers and its relation to lung function, airway symptoms and atopic predisposition. IP Indian J Immunol Respir Med 2019;4(4):210-213

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