- Visibility 27 Views
- Downloads 18 Downloads
- Permissions
- DOI 10.18231/j.ijirm.12546.1758514574
-
CrossMark
Association of nutritional status and respiratory muscle strength in patients with pulmonary tuberculosis - A cross-sectional study at a tertiary care hospital
- Author Details:
-
Veena Kiran Nambiar *
-
Gayathri Devi HJ
-
Rachana Nayak
-
Neil W Schluger
-
Keerthana M
-
Nirantha SP
Veena Kiran Nambiar *
Background: Pulmonary tuberculosis (PTB) dysfunction leads to fatigue, dyspnea, and poor quality of life (QOL), altering metabolism and muscle mass. This study aims to explore any association between nutritional status at the time of diagnosis and respiratory musclestrength after treatment in patients with PTB.
Materials and Methods: This cross-sectional study compared respiratory muscle strength in terms of maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP) among 52 subjects (26 cases and 26 controls) and serum albuminvalues as key outcome measuresof newly diagnosed PTB and withouta history of PTB.
Results: The MIP Median in the PTB group was 50 cm H2O compared to the controls 79 cm H2O. MEP Median in the PTB group was 57 cm H2O compared to controls at 70 cm H2O. There was a significant difference in MIP and MEP between PTB and controls at p < 0.05. A strong positive correlation (Pearsons) was seen between the serum albumin level and the MIP with a co-efficient of p < 0.05 and a moderate positive correlation with MEP.
Interpretation: There was an association between serum albumin level and respiratory muscle strength in PTB. A significant decrease in respiratory muscle strength was observed in individuals with PTB as compared to age-matched controls.
References
- Global tuberculosis report 2015, 20th ed. Accessed September 28,
- https://www.who.int/publications/i/item/9789241565059
- Ravimohan S, Kornfeld H, Weissman D, Bisson GP. Tuberculosis and lung damage: from epidemiology to pathophysiology. Eur Resp Rev. 2018;27(147):170077.
- Sharma NC. India aims to eliminate tuberculosis by 2025: Narendra Modi. mint. March 13, 2018. Accessed September 27, 2024. https://www.livemint.com/Politics/a3hJk9Sqqil1PZUtO0vAHN/P M-Modi-launches-campaign-to-eradicate-TB-from-India-by-
- html
- Di Naso FC, Pereira JS, Schuh SJ, Unis G. Functional evaluation in patients with pulmonary tuberculosis sequelae. Rev Port Pneumol. 2011;17(5):216–21.
- Mohamed-Hussein AAR, Salama SS, Khalil MA, Eid SA. Malnutrition in tuberculosis: value of fat-free mass and creatinine- height index. Egypt J Bronchol. 2016;10(1):58–63.
- Snyder CK, Lapidus JA, Cawthon PM, Dam TTL, Sakai LY, Marshall LM, et al. Serum albumin in relation to change in muscle mass, muscle strength, and muscle power in older men. J Am Geriatr Soc. 2012;60(9):1663–72.
- Palen J, Rea TD, Manolio TA, Lumley T, Newman AB, Tracy RP, et al. Respiratory muscle strength and the risk of incident cardiovascular events. Thorax. 2004;59(12):1063–7.
- Reid WD, Clarke TJ, Wallace AM. Respiratory muscle injury: evidence to date and potential mechanisms. Can J Appl Physiol. 2001;26(4):356–87.
- Skupien EC, Lazzari TK, Coutinho SE, Silva DR. The relation between leptin and inflammatory markers with respiratory and peripheral muscle strength in tuberculosis: A case-control study. Clin Respir J. 2018;12(11):2559–65.
- Ramakrishnan K, Shenbagarathai R, Kavitha K, Uma A, Balasubramaniam R, Thirumalaikolundusubramanian P. Serum zinc and albumin levels in pulmonary tuberculosis patients with and without HIV. Jpn J Infect Dis. 2008;61(3):202–4.
- Liu R, Shu W, Song Y, Liu Y, Ma L, Gao M. Use of Serum Albumin Level as a Predictive Marker of Clinical Outcomes for Active Tuberculosis. Ann Clin Lab Sci. 2020;50(5):681–6.
- Karyadi E, Schultink W, Nelwan RH, Gross R, Amin Z, Dolmans WM, et al. Poor micronutrient status of active pulmonary tuberculosis patients in Indonesia. J Nutr. 2000;130(12):2953–8.
- Nutritional care and support for patients with tuberculosis. Accessed September 28, 2024. https://www.who.int/publications/i/item/9789241506410
- Godoy MDP, Mello FCQ, Lopes AJ, Costa W, Guimarães FS, Pacheco AGF, et al. The functional assessment of patients with pulmonary multidrug-resistant tuberculosis. Respir Care. 2012;57(11):1949–4.
- Larisa Kiryukhina et al. Association of lung function disorders and the respiratory muscles strength in patients with tuberculosis (TB) and COPD. Eur Resp J. 2018;52(62):PA2716.