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- DOI 10.18231/j.ijirm.11865.1809767044
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CrossMark
- Citation
Urine microalbumin and albumin-creatinine ratio in COPD: Implications for perioperative and cardiovascular risk
- Author Details:
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Yusuf Barkati
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Ravi Shankar Mishra
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Mazher Maqsood
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Anjali Chauhan *
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Pradeep Nirala
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Abhishek Kumar
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Chinmay Jethi
Background: Chronic obstructive pulmonary disease (COPD) is associated with systemic inflammation and cardiovascular comorbidities that influence perioperative and critical care outcomes. Urinary microalbumin and the albumin-creatinine ratio (UACR) reflect endothelial dysfunction and microvascular disease. We evaluated their association with COPD severity and considered their potential utility in perioperative risk assessment.
Materials and Methods: In this observational study, stable COPD patients were stratified by Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. Spot urine samples were collected and analyzed for albumin and creatinine, and the UACR was calculated. We compared UACR across COPD severity groups and examined correlations with lung function and oxygenation indices.
Results: Consistent with prior reports, patients with advanced COPD had significantly higher urine microalbumin levels and UACR than those with mild disease. UACR increased progressively from GOLD stage I to IV. In our cohort, higher UACR was inversely correlated with FEV₁ and PaO₂ (p<0.01) and positively associated with symptom burden and hypoxemia, indicating systemic capillary leak in severe COPD.
Conclusions: Urine microalbuminuria and elevated UACR identify COPD patients with greater systemic vascular dysfunction and hypoxemia. Given their established prognostic value in cardiac surgery and critical care, these markers may help anesthesiologists assess cardiovascular risk in COPD patients. Routine preoperative screening for microalbuminuria could prompt intensified cardiovascular optimization and postoperative monitoring in this high-risk population.
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How to Cite This Article
Vancouver
Barkati Y, Mishra RS, Maqsood M, Chauhan A, Nirala P, Kumar A, Jethi C. Urine microalbumin and albumin-creatinine ratio in COPD: Implications for perioperative and cardiovascular risk [Internet]. IP Indian J Immunol Respir Med. 2025 [cited 2025 Oct 25];10(3):146-152. Available from: https://doi.org/10.18231/j.ijirm.11865.1809767044
APA
Barkati, Y., Mishra, R. S., Maqsood, M., Chauhan, A., Nirala, P., Kumar, A., Jethi, C. (2025). Urine microalbumin and albumin-creatinine ratio in COPD: Implications for perioperative and cardiovascular risk. IP Indian J Immunol Respir Med, 10(3), 146-152. https://doi.org/10.18231/j.ijirm.11865.1809767044
MLA
Barkati, Yusuf, Mishra, Ravi Shankar, Maqsood, Mazher, Chauhan, Anjali, Nirala, Pradeep, Kumar, Abhishek, Jethi, Chinmay. "Urine microalbumin and albumin-creatinine ratio in COPD: Implications for perioperative and cardiovascular risk." IP Indian J Immunol Respir Med, vol. 10, no. 3, 2025, pp. 146-152. https://doi.org/10.18231/j.ijirm.11865.1809767044
Chicago
Barkati, Y., Mishra, R. S., Maqsood, M., Chauhan, A., Nirala, P., Kumar, A., Jethi, C.. "Urine microalbumin and albumin-creatinine ratio in COPD: Implications for perioperative and cardiovascular risk." IP Indian J Immunol Respir Med 10, no. 3 (2025): 146-152. https://doi.org/10.18231/j.ijirm.11865.1809767044