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- DOI 10.18231/j.ijirm.12189.1837149538
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A cross-sectional study on the impact of methylxanthines, corticosteroids, and antibiotics on COPD symptoms: Assessment using CAT, mMRC, and GOLD criteria
Background: Chronic Obstructive Pulmonary Disease (COPD) is a long-term inflammatory lung condition marked by irreversible airflow limitation. This study aimed to assess the effectiveness of a combination therapy—methylxanthines, corticosteroids, and antibiotics—on symptom relief and exacerbation frequency in hospitalized patients with COPD, using the COPD Assessment Test (CAT) and the modified Medical Research Council (mMRC) dyspnea scale.
Materials and Methods: A six-month cross-sectional observational study was conducted at Government Medical College Hospital, Tiruppur, with prior approval from the Institutional Ethics Committee. A total of 120 hospitalized patients provided informed consent and were evaluated using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification system.
Results: Among the participants, 49% were aged between 46 and 60 years. Initially, 86% had high CAT scores (21–30), which improved to a moderate range (11–20) in 90% of patients following treatment. Most patients reported mMRC grade 3 breathlessness before therapy, which improved to grade 2 afterward. In the previous year, 87% had experienced exacerbations, and 82% required hospitalization. Based on improvements in CAT and mMRC scores, the majority of patients shifted from GOLD Group C (severe) (85%) to Group B (moderate) (92%) after treatment, showing a statistically significant change (p < 0.001).
Conclusion: The combination of methylxanthines, corticosteroids, and antibiotics demonstrated greater effectiveness in alleviating symptoms and reducing disease severity in COPD patients compared to a focus on exacerbation management alone.
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How to Cite This Article
Vancouver
Dhakchinamoorthi KK, Suseelan K, Sivanantham K, Moorthy G, Manickam B, Muruganandham S. A cross-sectional study on the impact of methylxanthines, corticosteroids, and antibiotics on COPD symptoms: Assessment using CAT, mMRC, and GOLD criteria [Internet]. IP Indian J Immunol Respir Med. 2025 [cited 2025 Oct 02];10(3):133-139. Available from: https://doi.org/10.18231/j.ijirm.12189.1837149538
APA
Dhakchinamoorthi, K. K., Suseelan, K., Sivanantham, K., Moorthy, G., Manickam, B., Muruganandham, S. (2025). A cross-sectional study on the impact of methylxanthines, corticosteroids, and antibiotics on COPD symptoms: Assessment using CAT, mMRC, and GOLD criteria. IP Indian J Immunol Respir Med, 10(3), 133-139. https://doi.org/10.18231/j.ijirm.12189.1837149538
MLA
Dhakchinamoorthi, Krishna Kumar, Suseelan, Kadhiravan, Sivanantham, Karthick, Moorthy, Gokulalakshmi, Manickam, Balaji, Muruganandham, Sivashanmugam. "A cross-sectional study on the impact of methylxanthines, corticosteroids, and antibiotics on COPD symptoms: Assessment using CAT, mMRC, and GOLD criteria." IP Indian J Immunol Respir Med, vol. 10, no. 3, 2025, pp. 133-139. https://doi.org/10.18231/j.ijirm.12189.1837149538
Chicago
Dhakchinamoorthi, K. K., Suseelan, K., Sivanantham, K., Moorthy, G., Manickam, B., Muruganandham, S.. "A cross-sectional study on the impact of methylxanthines, corticosteroids, and antibiotics on COPD symptoms: Assessment using CAT, mMRC, and GOLD criteria." IP Indian J Immunol Respir Med 10, no. 3 (2025): 133-139. https://doi.org/10.18231/j.ijirm.12189.1837149538