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Pharmacological screening of natural products for lung diseases: A comprehensive review
Respiratory diseases like asthma, Chronic Obstructive Pulmonary Disease (COPD), and lung cancer pose a significant global health burden, with existing treatments often limited by side effects, drug resistance, and high costs. This comprehensive review explores the potential of natural products as a rich and diverse source for novel therapeutic agents. It begins by outlining the pathophysiology and unmet medical needs for major lung diseases, followed by a discussion of the historical use of natural remedies in traditional medicine, which has provided a valuable starting point for modern drug discovery. The review details the methodologies of pharmacological screening, including collection, extraction, bioassay-guided fractionation, and the use of both in vitro and in vivo models. After analyze promising natural compounds like quercetin and curcumin for their anti-inflammatory and antioxidant activities in asthma and COPD, and highlighting the anti-proliferative effects of agents such as paclitaxel in lung cancer. The discussion critically addresses the challenges facing this field, including issues of standardization, poor bioavailability, and regulatory hurdles. Finally, the review proposes future directions, such as exploring synergistic combinations, leveraging computational methods, and developing advanced delivery systems to overcome these limitations. This paper underscores the importance of continued research into natural products to develop more effective and sustainable therapies for lung diseases.
References
- Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, et al. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2007;176(6):532–55.
- Agustí A, Celli BR, Criner GJ, Halpin D, Anzueto A, Barnes P, et al. Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary. Am J Respir Critl Care Med. 2023;207(7):819–37.
- GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet (London, England), 2018;392(10159):1789–858.
- Barnes PJ. New anti-inflammatory targets for chronic obstructive pulmonary disease. Nat Rev Drug Discov. 2013;12(7):543-59.
- Mathew J, Aronow WS, Chandy D. Therapeutic options for severe asthma. Arch Med Sci: AMS. 2012;8(4):589–97.
- Witschi H. A short history of lung cancer. Toxicol Sci. 2001;64(1):4-
- Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod. 2012;75(3):311-
- Dubey A, Shukla D, Kumari M, Gupta AK. Lung aging and climate exposures: Molecular processes and consequences for enhancing pulmonary health. IP Indian J Immunol Respir Med. 2025;10(2):44–
- Harvey AL. Natural products in drug discovery. Drug Discov Today. 2008;13(19-20);894–901.
- Harvey AL, Edrada-Ebel R, Quinn RJ. The re-emergence of natural products for drug discovery in the genomics era. Nat Rev Drug Discov. 2015;14(2):111–29.
- Butler MS. The role of natural product chemistry in drug discovery. J Nat Prod. 2004;67(12):2141–53.
- Cragg GM, Newman DJ. Natural products: a continuing source of novel drug leads. Biochimica Biophysica Acta, 2013;1830(6):3670–
- Barnes PJ. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2016;138(1):16–27.
- Hall S, Agrawal DK. Key mediators in the immunopathogenesis of allergic asthma. Int Immunopharmacol. 2014;23(1):316–29.
- Efferth T, Kahl S, Paulus K, Adams M, Rauh R, Boechzelt H, et al. Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells. Mol Cancer Ther. 2008;7(1):152–61.
- Amaral-Machado L, Oliveira WN, Moreira-Oliveira SS, Pereira DT, Alencar ÉN, Tsapis N, et al. Use of Natural Products in Asthma Treatment. Evid Based Complement Alternat Med. 2020:2020:1021258.
- Singh D, Higham A, Mathioudakis AG, Beech A. Chronic Obstructive Pulmonary Disease (COPD): Developments in Pharmacological Treatments. Drugs. 2025;85(7):911–30.
- Thomford NE, Senthebane DA, Rowe A, Munro D, Seele P, Maroyi A, et al. Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery. Int J Mol Sci. 2018;19(6):1578.
- Barnes PJ. Cellular and molecular mechanisms of asthma and COPD. Clin Sci (London, England: 1979). 2017;131(13):1541–58.
- Hekking PP, Wener RR, Amelink M, Zwinderman AH, Bouvy ML, Bel EH. The prevalence of severe refractory asthma. J Allergy Clin Immunol. 2015;135(4):896–902.
- Lambrecht BN, Hammad H. Allergens and the airway epithelium response: gateway to allergic sensitization. J Allergy Clin Immunol. 2014;134(3):499–507.
- Bateman ED, Boushey HA, Bousquet J, Busse WW, Clark TJ, Pauwels RA, et al. GOAL Investigators Group. Can guideline- defined asthma control be achieved? The Gaining Optimal Asthma ControL study. Am J Respir Crit Care Med. 2004;170(8):836–44.
- Delgado J, Navarro A, Álvarez-Gutiérrez FJ, Cisneros C, Domínguez-Ortega J. Necesidades no cubiertas en asma alérgica grave [Unmet Needs in Severe Allergic Asthma]. Open Respir Arch. 2023;5(4):100282.
- Bellinger CR, Peters SP. Outpatient Chronic Obstructive Pulmonary Disease Management: Going for the GOLD. J Allergy Clin Immunol Pract. 2015;3(4):471–80.
- Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, Buzatu L, et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med. 2004;350(26):2645–53.
- Burkes RM, Donohue JF. An Update on the Global Initiative for Chronic Obstructive Lung Disease 2017 Guidelines with a Focus on Classification and Management of Stable COPD. Respir Care. 2018;63(6):749–58.
- Barnes PJ. Novel approaches and targets for treatment of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999;160(5 Pt 2):S72–9.
- Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–49.
- Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2012;144(5):646–74.
- Nishio K, Nakamura T, Koh Y, Suzuki T, Fukumoto H, Saijo N. (1999). Drug resistance in lung cancer. Curr Opin Oncol. 1999;11(2):109–15.
- Li XM, Brown L. Efficacy and mechanisms of action of traditional Chinese medicines for treating asthma and allergy. J Allergy Clin Immunol. 2009;123(2):297–308.
- Cohen MM. Tulsi - Ocimum sanctum: A herb for all reasons. J Ayurveda Integr Med. 2014;5(4):251–9.
- Li X. M. Traditional Chinese herbal remedies for asthma and food allergy. J Allergy Clin Immunol. 2007;120(1):25–31.
- Montinari MR, Minelli S, De Caterina R. The first 3500 years of aspirin history from its roots - A concise summary. Vascul Pharmacol. 2019;113:1–8.
- Tu Y. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nat Med. 2011;17(10);1217–20.
- Almatroodi SA, Alsahli MA, Rahmani AH. Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways. Molecules (Basel, Switzerland). 2022;27(18):5889. 120 Dubey et al / IP Indian Journal of Immunology and Respiratory Medicine 2025;10(3):110-121
- Tang S, Ren J, Kong L, Yan G, Liu C, Han Y, et al. Ephedrae Herba: A Review of Its Phytochemistry, Pharmacology, Clinical Application, and Alkaloid Toxicity. Molecules (Basel, Switzerland). 2023;28(2):663.
- Zhao C, Ding Y, Huang Y, Wang C, Guo B, Zhang T. Quercetin Attenuates MRGPRX2-Mediated Mast Cell Degranulation via the MyD88/IKK/NF-κB and PI3K/AKT/ Rac1/Cdc42 Pathway. J Inflamm Res. 2024;17:7099–110.
- Safari S, Davoodi P, Soltani A, Fadavipour M, Rezaeian A, Heydari F, et al. Curcumin effects on chronic obstructive pulmonary disease: A systematic review. Health Sci Rep. 2023;6(3):e1145.
- Faulkner DJ. Marine natural products. Nat Prod Rep. 2002;19(1):1–
- Khalifa SAM, Elias N, Farag MA, Chen L, Saeed A, Hegazy MF, et al. Marine Natural Products: A Source of Novel Anticancer Drugs. Mar Drugs. 2019;17(9):491.
- Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007;70(3):461–77.
- Penesyan A, Kjelleberg S, Egan S. Development of novel drugs from marine surface associated microorganisms. Mar Drugs. 2010;8(3):438–59.
- Farnsworth NR. The role of ethnopharmacology in drug development. Ciba Foundation Symposium. 2007;154:2–21. https://doi.org/10.1002/9780470514009.ch2
[Google Scholar] - Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environ Health Perspect. 2001;109 Suppl 1(Suppl 1):69–75.
- Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc. 1971;93(9):2325–7.
- Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Life Sci. 2005;78(5):431–41.
- Zare'i M, Rabieepour M, Ghareaghaji R, Zarrin R, Faghfouri AH. Nanocurcumin supplementation improves pulmonary function in severe COPD patients: A randomized, double blind, and placebo- controlled clinical trial. Phytother Res. 2024;38(3):1224–34.
- Saadat S, Beigoli S, Khazdair MR, Amin F, Boskabady MH. Experimental and Clinical Studies on the Effects of Natural Products on Noxious Agents-Induced Lung Disorders, a Review. Front Nutr. 2022;9:867914.
- Zafari M. The effects of some natural products on lung disorders: a systematic review. J Pharmacol Rep. 2021;6(1):1–10.
- Sierocinski E, Holzinger F, Chenot JF. Ivy leaf (Hedera helix) for acute upper respiratory tract infections: an updated systematic review. Eur J Clin Pharmacol. 2021;77(8):1113–22.
- Maqbool A, Khan MZ, Begum S, Kiran A. Efficacy of Ivy Leaf Extract Syrup in Managing Bronchial Asthma among Children: A Prospective Observational Study. RABCS. 2025;3(1):41-5.
- Areej SR, Khan MS, Khan MGJ. Assessment of Nigella sativa (Black Seed) Supplementation in Improving Asthma Control among Adolescents. Innovative Res J Appl Biol Chem Sci. 2025;1(1):14-
- Khazdair MR, Amirabadizadeh A. Therapeutic effects of Nigella sativa on asthma: a systematic review of clinical trial. Phytopharmacology J. 2022;1(1):22–9.
- Raskin I, Ribnicky DM, Komarnytsky S, Ilic N, Poulev A, Borisjuk N, et al. Plants and human health in the twenty-first century. Trends Biotechnol. 2002;20(12):522–31.
- Sasidharan S, Chen Y, Saravanan D, Sundram KM, Yoga Latha L. Extraction, isolation and characterization of bioactive compounds from plants' extracts. Afr J Tradit Complement Altern Med. 2011;8(1):1–10.
- Shahi S, Singh SK. Phytochemical Analysis and Characterization of Cancer-Cure Medicinal Plants: A Comprehensive Review. Int J Environ Sci. 2025;11(10s):592–606.
- Ponphaiboon J, Krongrawa W, Aung WW, Chinatangkul N, Limmatvapirat S, Limmatvapirat C. Advances in Natural Product Extraction Techniques, Electrospun Fiber Fabrication, and the Integration of Experimental Design: A Comprehensive Review. Molecules (Basel, Switzerland), 2003;28(13):5163.
- Dai J, Mumper RJ. Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties. Molecules. 2010;15(10):7313–52.
- Wang L. Weller CL. Recent Advances in Extraction of Nutraceuticals from Plants. Trends Food Sci Technol. 2006;17;(6)300–12.
- Cragg GM, Newman DJ, Snader KM. Natural products in drug discovery and development. J Nat Prod. 1997;60(1):52–60.
- Beutler JA. Natural Products as a Foundation for Drug Discovery. Curr Protoc Pharmacol. 2009:46:9.11.1–9.
- Zhang QW, Lin LG, Ye WC. Techniques for extraction and isolation of natural products: a comprehensive review. Chinese Med. 2018;13:20.
- Quirantes-Piné R, Funes L, Micol V, Segura-Carretero A, Fernández-Gutiérrez A. High-performance liquid chromatography with diode array detection coupled to electrospray time-of-flight and ion-trap tandem mass spectrometry to identify phenolic compounds from a lemon verbena extract. J Chromatogr. 2009;1216(28):5391–
- Singh K, Gupta JK, Chanchal DK, Shinde MG, Kumar S, Jain D et al. Natural products as drug leads: exploring their potential in drug discovery and development. Naunyn-Schmiedeberg's Arch Pharmacol. 2025;398(5):4673–87.
- Kim MH, Bae CS, Bok SH, Choi HS, Ahn T, Cho SS, et al. Drug Development from Natural Products Based on the Pathogenic Mechanism of Asthma. Int J Mol Sci. 2023;24(15):12469.
- Banerjee S, Chanda A, Adhikari A, Das A, Biswas S. Evaluation of Phytochemical Screening and Anti-Inflammatory Activity of Leaves and Stem of Mikania scandens (L.) Wild. Ann Med Health Sci Res. 2014;4(4), 532–6.
- Miguel MG. Antioxidant and anti-inflammatory activities of essential oils: a short review. Molecules (Basel, Switzerland). 2010;15(12):9252–87.
- Kedare SB, Singh RP. Genesis and development of DPPH method of antioxidant assay. J Food Sci Technol. 2011;48(4):412–22.
- Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine, 5th edn (Oxford, 2015; online edn, Oxford Academic, 22 Oct. 2015). https://doi.org/10.1093/acprof:oso/9780198717478.001.0001
[Google Scholar] - McIntyre HJ, Temple DM. The effects of some bronchodilator and anti-inflammatory drugs on prostaglandin F2alpha-induced contraction of guinea-pig isolated trachea. Clin Exp Pharmacol Physiol. 1977;4(2):165–71.
- Yousif MH, Thulesius O. Forskolin reverses tachyphylaxis to the bronchodilator effects of salbutamol: an in-vitro study on isolated guinea-pig trachea. J Pharm Pharmacol. 1999;51(2):181–6.
- Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Method. 1983;65(1-2):55–63.
- Wlodkowic D, Skommer J, Darzynkiewicz Z. Flow cytometry- based apoptosis detection. Method Mol Biol (Clifton, N.J.). 2009;559:19–32.
- Zosky GR, Sly PD. Animal models of asthma. Clin Exp Allergy. 2007;37(7):973–88.
- Takeda K,Gelfand EW. Mouse models of allergic diseases. Curr Opin Immunol. 2009;21(6):660–5.
- Vlahos R, Bozinovski S, Gualano RC, Ernst M, Anderson GP. Modelling COPD in mice. Pulmon Pharmacol Ther. 2006;19(1):12–
- Macarron R, Banks MN, Bojanic D, Burns DJ, Cirovic DA, Garyantes T, et al. Impact of high-throughput screening in biomedical research. Nat Rev Drug Discov. 2011;10(3):188–95.
- Inglese J, Johnson RL, Simeonov A, Xia M, Zheng W, Austin CP, et al. High-throughput screening assays for the identification of chemical probes. Nat Chem Biol. 2007;3(8):466–79.
- Coussens NP, Sittampalam GS, Guha R, Brimacombe K, Grossman A, Chung TDY, et al. Assay Guidance Manual: Quantitative Biology and Pharmacology in Preclinical Drug Discovery. Clin Transl Sci. 2008;11(5):461–70.
- Shahi S, Singh, SK Medicinal Plants: A Feast for Animals (But Not Quite). Afr J Biol Sci. 2024;6(11):1862–70. Dubey et al / IP Indian Journal of Immunology and Respiratory Medicine 2025;10(3):110-121 121
- Sagit M, Polat H, Gurgen SG, Berk E, Guler S, Yasar M. Effectiveness of quercetin in an experimental rat model of allergic rhinitis. Eur Arch Otorhinolaryngol. 2017;274(8);3087–95.
- Chirumbolo S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm Allergy Drug Targets. 2010;9(4);263–85.
- Weng Z, Zhang B, Asadi S, Sismanopoulos N, Butcher A, Fu X, et al. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PloS one, 2012;7(3):e33805.
- Mlcek J, Jurikova T, Skrovankova S, Sochor J. Quercetin and Its Anti-Allergic Immune Response. Molecules (Basel, Switzerland). 2016;21(5):623.
- Buhrmann C, Mobasheri A, Busch F, Aldinger C, Stahlmann R, Montaseri A, et al. Curcumin modulates nuclear factor kappaB (NF- kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem. 2011;286(32):28556–66.
- Hewlings SJ, Kalman DS. Curcumin: A Review of Its Effects on Human Health. Foods (Basel, Switzerland), 2017;6(10):92.
- Beijers RJHCG, Gosker HR, Schols AMWJ. Resveratrol for patients with chronic obstructive pulmonary disease: hype or hope? Curr Opin Clin Nutr Metab Care. 2018;21(2):138–44.
- Zeng XL, Yang XN, Liu XJ. Resveratrol attenuates cigarette smoke extract induced cellular senescence in human airway epithelial cells by regulating the miR-34a/SIRT1/NF-κB pathway. Medicine. 2022;101(46):e31944.
- Jin F, Lin H, Pan S. Novel therapeutic strategy: Nrf2 activation in targeting senescence-related changes in chronic obstructive pulmonary disease. J Thorac Dis. 2025;17(2):623–40.
- Jiao Z, Chang J, Li J, Nie D, Cui H, Guo D. Sulforaphane increases Nrf2 expression and protects alveolar epithelial cells against injury caused by cigarette smoke extract. Mol Med Rep. 2017;16(2):1241–
- Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT. Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc. 1971;93(9):2325–27.
- Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nature reviews. Cancer. 2004;4(4):253–65.
- Chen Q, Wang Y, Xu K, Lu G, Ying Z, Wu L, et al.Curcumin induces apoptosis in human lung adenocarcinoma A549 cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Oncol Rep. 2010;23(2):397-403.
- Zheng SY, Li Y, Jiang D, Zhao J, Ge JF. Anticancer effect and apoptosis induction by quercetin in the human lung cancer cell line A-549. Mol Med Rep. 2012;5(3):822–6.
- Zhu Y, Ouyang Z, Du H, Wang M, Wang J, Sun H, et al. New opportunities and challenges of natural products research: When target identification meets single-cell multiomics. Acta Pharm Sinica. B. 2022;12(11);4011–39.
- Ahamed M. Quality Control of Herbal Medicinal Products. In Bioactive Phytochemicals: Drug Discovery to Product Development Bentham Science Publishers. 2020:143–57.
- Maheshwari M. Investigating the Role of Natural Products and Traditional Medicine in Modern Pharmacology. Res J Appl Sci. 2025;12(1):1-10.
- Pan Y. Quality Control and Standardization of Herbal Medicinal Products: Recent Advancements. J Fun Foods. 2024;10(2):20–5.
- Maheshwari S, Shahi S. AI-Powered Mining of Nature's Chemical Library: Unveiling the Therapeutic Potential of Natural Products. Res J Pharm. 2024;18(3):32–7.
- Dzobo K. The Role of Natural Products as Sources of Therapeutic Agents for Innovative Drug Discovery. Compr Pharm. 2022;408–
- Wang H, Chen Y, Wang L, Liu Q, Yang S, Wang C. Advancing herbal medicine: enhancing product quality and safety through robust quality control practices. Front Pharmacol. 2023;14:1265178.
- Sachdeva A, Dhawan D, Jain GK, Yerer MB, Collignon TE, Tewari D, et al. Novel Strategies for the Bioavailability Augmentation and Efficacy Improvement of Natural Products in Oral Cancer. Cancers. 2022;15(1):268.
- Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007;4(6):807–18.
- Swartz HM, Mason RP, Hogg N, Kalyanaraman B, Sarna T, Plonka PM, et al. Free Radicals and Medicine. Biomedical EPR, Part A: Free Radicals Metals Med Physiol. 2005;23:25–74.
- Tripathy P, Shahi S. AI‐Powered Mining of Nature's Chemical Library:Unveiling the Therapeutic Potential of Natural Products. Res J Pharmacol. 2024;18(3):32–7.
- Mathew J, Aronow WS, Chandy D. Therapeutic options for severe asthma. Arch Med Sci. 2012;8(4):589–97.
- Witschi H. A short history of lung cancer. Toxicol Sci. 2001;64(1):4–
- Rates SM. Plants as source of drugs. Toxicon: official journal of the International Society on Toxinology. 2001;39(5);603–613.
- Macarron R, Banks MN, Bojanic D, Burns DJ, Cirovic DA., Garyantes T, et al. Impact of high-throughput screening in biomedical research. Nat Rev. Drug Dis. 2001;10(3):188–95.
- Markossian S, Grossman A, Baskir H, Arkin M, Auld D, Austin C, et al. Assay Guidance Manual. Eli Lilly & Company and the National Center for Advancing Translational Sciences. 2004
- Naso M, Trincianti C, Tosca MA, Ciprandi G. Quercetin and its lecithin-based formulation: Potential applications for allergic diseases based on a narrative review. Nutrients. 2025;17(9):1476.
- Beijers RJ, Gosker HR, Sanders KJ, Theije C, Kelders M, Clarke G. et al. Resveratrol and metabolic health in COPD: A proof-of- concept randomized controlled trial. Clin Nut. 2020;39(5):1629–36.
- Harvey CJ, Thimmulappa RK, Sethi S, Kong X, Yarmus L, Brown RH, et al. Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model. Sci Transl Med. 2011;3(78):78ra32.
- Ramalingam SS. Nivolumab with or without nab-paclitaxel in previously treated, advanced-stage non-small cell lung cancer: a randomized phase II study. Clin Lung Cancer. 2018;19(5);450–58.
How to Cite This Article
Vancouver
Dubey A, Shahi S, Mishra R, Dash SL, Samanthula KS. Pharmacological screening of natural products for lung diseases: A <span style="font-size: 1rem;">comprehensive review</span> [Internet]. IP Indian J Immunol Respir Med. 2025 [cited 2025 Oct 02];10(3):110-121. Available from: https://doi.org/10.18231/j.ijirm.12778.1957379553
APA
Dubey, A., Shahi, S., Mishra, R., Dash, S. L., Samanthula, K. S. (2025). Pharmacological screening of natural products for lung diseases: A <span style="font-size: 1rem;">comprehensive review</span>. IP Indian J Immunol Respir Med, 10(3), 110-121. https://doi.org/10.18231/j.ijirm.12778.1957379553
MLA
Dubey, Anubhav, Shahi, Sanyogita, Mishra, Rajesh, Dash, Sribatsa Lanchhana, Samanthula, Kumara Swamy. "Pharmacological screening of natural products for lung diseases: A <span style="font-size: 1rem;">comprehensive review</span>." IP Indian J Immunol Respir Med, vol. 10, no. 3, 2025, pp. 110-121. https://doi.org/10.18231/j.ijirm.12778.1957379553
Chicago
Dubey, A., Shahi, S., Mishra, R., Dash, S. L., Samanthula, K. S.. "Pharmacological screening of natural products for lung diseases: A <span style="font-size: 1rem;">comprehensive review</span>." IP Indian J Immunol Respir Med 10, no. 3 (2025): 110-121. https://doi.org/10.18231/j.ijirm.12778.1957379553